Cell Pathology

Anita Sjölander

Research

The tumor microenvironment in the context of colon cancer and with a focus on the inflammatory mediators leukotriene D₄ (LTD₄) and prostaglandins (PGE₂) and their respective receptors. These mediators and their receptors are enriched in colon cancer cells and colon cancer tissues, which demonstrate there, contribute to tumor development and progression. Several of the observations and ideas are generated from our analyses of human colon cancer materials. Our aim is to generate solid support for novel and complementary treatments of colon cancer patients that focus on the inflammatory component of the tumor microenvironment.

Staff

Anita Sjölander

Professor Cell Pathology
Phone: +46 40 391168
E-mail: Anita [dot] Sjolander [at] med [dot] lu [dot] se (Anita[dot]Sjolander[at]med[dot]lu[dot]se)

Janina Osman

Ph.D. student
Phone: +46 40 391176
E-mail: Janina [dot] Osman [at] med [dot] lu [dot] se (Janina[dot]Osman[at]med[dot]lu[dot]se)
Research project focuses on colon cancer and how inflammatory receptors affect cancer growth and outcome. Inflammation is known to contribute to cancer development. I am interested in colon cancer, one of the most common cancers in the world, and specifically how the microenvironment and cancer interact with one another. Our research focuses on proteins involved in inflammation, specifically the involvement of cysteinyl leukotriene receptors. We investigate how the lack of these receptors affects tumour growth and the surrounding tumour microenvironment in different colon cancer models.

Geriolda Topi

Ph.D. student
Phone:+46 40 391183
E-mail: geriolda [dot] topi [at] med [dot] lu [dot] se (geriolda[dot]topi[at]med[dot]lu[dot]se)
Geriolda Topi is a medical doctor being specialized in endocrinology. Her focus of research is the role of estrogen and thyroid hormones in colon cancer progression and their effects on inflammatory components of the tumor microenvironment, in a big female cohort.

Shakti Ranjan Satapathy

Ph.D., Post-Doc

Phone: +46 40 391176
E-mail: shakti_ranjan [dot] satapathy [at] med [dot] lu [dot] se (shakti_ranjan[dot]satapathy[at]med[dot]lu[dot]se)
Cancer research with focus on tumour microenvironment and cell migration/metastasis

Syrina Mehrabi

Ph.D. student
Phone: +46 40 391183
E-mail: syrina [dot] mehrabi [at] med [dot] lu [dot] se (syrina[dot]mehrabi[at]med[dot]lu[dot]se)
Syrina is a pharmacist and her research in cell pathology focuses on neutrophils recruitment in colorectal cancers microenvironment and in cancer related inflammation. Neutrophils are one of the most common inflammatory mediators in tumors which secretes a large amount of leukotrienes. It´s still not clear what role the infiltration of neutrophils in colorectal cancer have and how many types of neutrophils exist that interact with cancer and its effect on CRC microenvironment.

Pujarini Dash

Ph.D., Post-Doc
Puja has done her first post-doctoral training on the cross-talk between pancreatic cancer and its microenvironment. Now, she is interested in the interaction between the immune cells (mainly mast cells) present in the colon cancer microenvironment and colon cancer cells. Her focus is to target the tumor microenvironment for developing new and effective therapeutic strategies.

Lubna Mehdawi

Ph.D., Post-doc

Phone: +46 40 391183
E-mail: Lubna [dot] Mehdawi [at] med [dot] lu [dot] se (Lubna[dot]Mehdawi[at]med[dot]lu[dot]se)
Lubnas research is mainly focused on the tumor suppressor protein 15-hydroxyprostaglandin dehydrogenase which is known to be down-regulated in colon cancer. She is investigating two different ligands and their receptive G-protein coupled receptors WNT5A/Frizzle and cysteinyl leukotriene C4/CysLTR2 signaling pathways which both upregulates 15-PGDH and induce re-differentiation of colon cancer cells. High levels of 15-PGDH correlates with longer survival of colon cancer patients. Her research involves methods as tissue microarray (TMA) of colon cancer patients for immunohistochemistry (IHC) and Western blot, qPCR, transfection, luciferase assay, immunofluorescens on colon cancer cell lines.

Caroline Lindö

Ph.D., Laboratorieingenjör